In the race to develop new and better vaccines and boosters to block COVID-19, scientists are eagerly seeking laboratory tests that can measure immune responses to quickly show how well these shots are working, instead of waiting months for results of clinical trials involving tens of thousands of people.

Now, a group of top scientists, including Dr. Peter Gilbert, a biostatistician at Seattle’s Fred Hutchinson Cancer Research Center, are reporting that they have defined such measurements — or correlates of protection — for the widely used Moderna mRNA vaccine.

Our most recent graduates will now embark on new careers, continue research, or continue their education pursuing advanced degrees.  Here is a sample of their exceptional work in the program and their future plans. 

Finding a surrogate measure of efficacy should speed regulators' decisions on vaccine approval even without large placebo-controlled studies, which could be impracticable to carry out if vaccines become widely available, said Peter Gilbert, a researcher at Fred Hutchinson and an author of the recent study.

Eagerly anticipated new research pinpoints antibodies scientists can test for to see if a COVID-19 vaccine is effective. These "correlates of protection" could speed the development of new vaccines or boosters without requiring the enormous clinical trials used to create the first COVID-19 vaccines. This is "the Holy Grail" in terms of vaccines, and one that hasn't yet been set for the virus that causes COVID-19, said Peter Gilbert, co-author of the study posted August 10 to medRxiv and a UW research professor of biostatistics.

Biostatistics faculty Lianne Sheppard, Marco Carone and Adam Szpiro were members of a UW Department of Environmental & Occupational Health Sciences (DEOHS) research team that found Puget Sound residents exposed to higher levels of fine particulate air pollution over a 10-year period had a greater risk of developing dementia.