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Ancestry-specific genetic variation at APOE Alzheimer’s gene modifies disease risk

UW School of Public Health

In a new study of more than 3,000 Caribbean Hispanics, researchers from the University of Washington found that individuals with African ancestry at a key Alzheimer’s gene had 39 percent lower odds of developing Alzheimer’s disease than individuals with European ancestry at the gene. “The results from our study have important implications for the use of personalized genetic risk in populations with diverse ancestries, even for well-established risk factors,” said senior author Tim Thornton, associate professor of biostatistics at the UW School of Public Health.

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