Research methods for evaluating genetic influences on disease and risk factors and for assessing genetic-environment interactions. Study designs and statistical methods that are covered include twin studies, family-based studies, genome-wide association studies, rare variant association studies and Mendelian randomization studies. Prerequisites: either EPI 511 or equivalent; either BIOST 511 or equivalent; and either BIOST 509, experience with R programming language, or experience with other programming software; recommended: either GENOME 371 or equivalent. Offered: jointly with EPI 517; Spring