Eagerly anticipated new research pinpoints antibodies scientists can test for to see if a COVID-19 vaccine is effective. These "correlates of protection" could speed the development of new vaccines or boosters without requiring the enormous clinical trials used to create the first COVID-19 vaccines. This is "the Holy Grail" in terms of vaccines, and one that hasn't yet been set for the virus that causes COVID-19, said Peter Gilbert, co-author of the study posted August 10 to medRxiv and a UW research professor of biostatistics.
Alumni in the News
Fred Hutch researcher and UW Biostatistics alum Elizabeth Krantz (MS, '00) co-led a project that examined how much protection cancer patients have against measles and mumps. "Our findings really emphasize the need to increase immunity at the community level, particularly among health care workers or caregivers who have frequent contact with cancer patients."
"Think of the vaccine as a sieve and different variants as pebbles poured into the sieve: the vaccine will block some variants but allow others to pass through, and sieve analysis learns which variants make it through." — Peter Gilbert, biostatistician at the Fred Hutch Vaccine and Infectious Disease and Public Health Sciences Divisions and a UW research professor of biostatistics.
“The WHI has been remarkably productive in pursuing a broad range of scientific questions important to women,” said Garnet Anderson (PhD ’89) director of the Hutch's Public Health Sciences division and principal investigator of the Women’s Health Initiative (WHI) clinical coordinating center. Anderson is also an affiliate professor of biostatistics with the University of Washington School of Public Health.
When COVID-19 burst onto the scene last winter, and Tony Fauci, head of the National Institute of Allergy and Infectious Diseases, was looking for a way to run massive, credible and rigorous trials of potential vaccines, he turned to experts at the HIV Vaccine Trials Network (HVTN) based at the Fred Hutchinson Cancer Research Center. Co-principal investigators of the HVTN Statistics and Data Management Center include three researchers who are also University of Washington School of Public Health faculty: Peter Gilbert (Biostat), Holly Janes (Biostat), and Yunda Huang (Global Health).
Biostatistics alum Xihong Lin (MS ’92, PhD ’94) is the recipient of the 2021 L. Adrienne Cupples Award for Excellence in Teaching, Research, and Service in Biostatistics. The award is presented by the Department of Biostatistics at the Boston University School of Public Health. Lin, a pioneer in statistical methods for analysis of whole genome sequencing studies, was also recently named one of 50 Changemakers of Public Health by the UW School of Public Health.
Affiliate Professor of Biostatistics and Fred Hutch biostatistician Holly Janes participated in discussions about the design of HIV vaccine trails in the era of oral PrEP. “There are a lot of people who are interested in PrEP, but cannot sustain that over time,” she said. “One reason has to do with the usual challenges of getting people to change their behaviors when they are healthy. An analogy might be the difficulty in getting people to floss their teeth on a daily basis. It’s difficult for all of us,” said Janes.