This module introduces the R statistical environment, assuming no prior knowledge. It provides a foundation for the use of R for computation in later modules. In addition to discussing basic data management tasks in R, such as reading in data and producing summaries through R scripts, we will also introduce R's graphics functions, its powerful package system, and simple methods of looping. Hands-on use of R is a major component of this module; users require a laptop and will use it in all sessions. Examples and exercises will use data drawn from biological and medical applications, including infectious diseases and genetics. Participants require a laptop and will use it in all sessions.