Charles Wolock

Charles Wolock
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I am a PhD student in Biostatistics. I graduated from Harvard University in 2015 with a BA in Organismic and Evolutionary Biology, and a Spanish language citation. After completing my undergraduate degree, I worked as a research associate at the Institute for Genomic Medicine at Columbia University Medical Center, supervised by David Goldstein, PhD and Andrew Allen, PhD. My research focused primarily on non-invasive prenatal testing and rare variant association testing.

Currently, my interests revolve around decision theory, semiparametric and nonparametric statistics, and disease risk prediction models. I have been working with Dr. Lurdes Inoue and Dr. Gary Chan, taking a decision-theoretic approach to estimate the individualized incremental value of biomarkers in a risk prediction setting. Our goal is to develop a framework for estimating the value of using an expanded risk model, requiring additional biomarkers, in addition to baseline information collected about an individual. This involves estimating operating characteristics of the expanded risk model within subgroups defined by baseline covariates. I am also involved in a research project with Dr. Aasthaa Bansal and Dr. Patrick Heagerty, characterizing the differences between “locally optimal” sequential decision-making versus the full backwards induction “globally optimal” solution.

Outside of school, I enjoy backpacking, skiing, music, baking, and spending time with my dog. 

Organismic and Evolutionary Biology
Harvard University