Fred Hutch Biostatistics Faculty Candidate Seminar: Shulei Wang

Presentation: Phylogenetically Informed Methods for Microbiome Data Analysis--An Optimal Transport Perspective

Speaker: Shulei Wang, PhD, Postdoctoral Researcher, Department of Statistics, University of Pennsylvania

Abstract: It is increasingly recognized that human host-microbiome interactions play important roles in human health, from metabolism to immune system. However, analysis of human microbiome data poses great challenges in robust quantification and interpretation, due to the unique characteristics of the data, including high-dimensional compositional data, stochastic noise in composition, and a phylogenetic tree structure among the variables. In the talk, I will discuss the analysis strategies of such noisy tree-structure compositional data and share some of our recent efforts to ease such challenges from an optimal transport perspective. Specifically, I will present a new minimax optimal estimator for the Wasserstein distance on tree and introduce a novel interpretable two-sample test by leveraging the tree structure. The practical merit of the proposed methods is demonstrated by an application to a human intestinal biopsy microbiome data set for patients with inflammatory bowel disease.

Date/Time
Tue, Jan 28, 2020, 1:30pm to 2:30pm
Location
Room M4-A805/817, Arnold Building, Fred Hutch