10th Annual Summer Institute in Statistics and Modeling in Infectious Diseases (SISMID)

Module 5: Infectious Diseases, Immunology and Within-Host Models

Session 2: Wed Jul 11 to Fri Jul 13

Module dates/times: Wednesday, July 11, 1:30-5 p.m.; Thursday, July 12, 8:30 a.m.-5 p.m., and Friday, July 13, 8:30 a.m.-5 p.m.

Recommended but not required: Prior knowledge of R is helpful but not required.

This module provides an introduction to infectious diseases, the main components of the immune system, and mathematical modeling. Using pathogens such as HIV, TB, malaria, influenza and others, this module will introduce basic immunological concepts and explain how to use mathematical models to study aspects of within-host infection dynamics.

The focus will be on simple compartmental deterministic models. The use of those models to analyze the dynamics of pathogens, innate and adaptive immune responses and to design and evaluate intervention strategies, such as vaccines and drug treatments, are covered. Hands-on exercises using the programming language R will show how to construct and implement models.