Module date/time: Thursday, July 26, 8:30 a.m.-5 p.m.
This module will cover advanced topics in survival analysis, with an emphasis on applications in randomized clinical trials (RCTs) with censored time-to-event outcomes. The module will:
- Review the logrank test and introduce testing procedures that weight group comparisons differently over the follow-up time interval;
- Introduce the restricted mean survival time and tests to compare it between groups;
- Review methods suitable for examining the adjusted association between an explanatory variable and a censored event-data outcome;
- Cover how information is accrued when there is group-sequential monitoring, and
- Cover power and sample size computations for an RCT with censored time-to-even outcomes.
The course will focus on application and understanding the concepts with examples from the literature; mathematical details will be kept to a minimum. Knowledge of material in the Module 11: Introduction to Survival Analysis will be assumed.