22nd Summer Institute in Statistical Genetics

Module 7: Association Mapping: GWAS and Sequencing Data

Week 2, Session 3, Monday 8:30 AM - Wednesday 12:00 PM: Mon Jul 17 to Wed Jul 19

This module will provide students with the basic tools to carry out genetic association analysis within the context of genome wide association studies (GWAS) and next-generation sequencing studies with considerable emphasis on hands-on learning.

Topics covered include: case-control (disease) association testing; quantitative trait analysis; quality control processes in GWAS; multi-locus testing using gene and pathway information; population structure and ancestry inference; association testing in the presence of population structure and/or relatedness; gene-environment and gene-gene interactions; basic rare variant association analysis in sequencing studies; advanced rare variant methods; sequence kernel association tests (SKAT); meta analysis; design considerations; and other emerging topics.

An important component of this module is in-class software exercises which will provide students with hands-on experience analyzing real data using state-of-the-art analysis tools for GWAS and next generation sequencing data.

Assumes basic familiarity with R. Other public domain software that will be used includes PLINK.