This module will cover more advanced topics in survival analysis, with an emphasis on applications in clinical trials. Knowledge of material in the “Introduction to Survival Analysis” module will be assumed. We will introduce methods suitable for testing hypotheses about a variety of quantitative summaries of the discrepancy between treatment groups’ survival. The choice of outcome event for the primary analysis will be considered. We will also discuss adjustment for prognostic variables using stratification and regression methods, and estimation of power and sample size. The course will focus on application and understanding the concepts; mathematical details will be kept to a minimum.