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The Department of Biostatistics is privileged to be part of a large and dynamic community of statisticians and biostatisticians in Seattle. We have a strong partnership with the University of Washington Department of Statistics. Other colleagues are at the nearby Fred Hutchinson Cancer Research Center in its Public Health Sciences Division, the VA Puget Sound Health Care System, and the Group Health Research Institute.

Faculty in the Department of Biostatistics collaborate with scientific colleagues in hundreds of different areas of medical and biological research. Many collaborators are faculty in other departments in the School of Public Health or the School of Medicine at the University.

Some larger projects with leadership from within the Department of Biostatistics include:

Center for Biomedical Statistics (CBS); Patrick Heagerty, Director: Statistical collaboration for the University of Washington Institute of Translational Health Sciences (ITHS) investigators and trainees is coordinated through the Center for Biomedical Statistics (CBS). The CBS has also entered into a collaboration with the Center for Inherited Disease Research (CIDR) at Johns Hopkins University to provide statistical and analytical support for the interpretation of genetic data. Specific guidance regarding design and analysis options for proposed studies is provided, including assistance in the preparation of grant proposals. The CBS also provides expertise in conjunction with Biomedical Informatics to ensure timely and thorough data collection, and quality assurance review.

Collaborative Health Studies Coordinating Center (CHSCC); Richard Kronmal, Director and Co-Principal Investigator of CHS, MESA, SEA, and other studies; Lyn Brumback, Co-Principal Investigator of ISIS; Elizabeth Brown, Co-Principal Investigator of the HIV Study. The CHSCC is dedicated to the design, operations, and statistical support of multi-site epidemiologic studies and randomized trials for the prevention and treatment of health conditions and disease. Larger studies facilitated by the Center are the Cardiovascular Health Study, the Multi-Ethnic Study of Atherosclerosis, the Ginkgo Evaluation of Memory Study, and the Early Steps Study of Autism.

UW Clinical Trial Center (UWCTC); Susanne May, Principal Investigator for Resuscitation Outcomes Consortium (ROC); Gerald van Belle, Principal Investigator for PROPPR Study. The Center’s Resuscitation Outcomes Consortium provides infrastructure and project support for clinical trials and other outcome-oriented research in the areas of cardiopulmonary arrest and severe traumatic injury that will rapidly lead to evidence-based change in clinical practice. The focus on pre-hospital and early hospitalization interventions recognizes the critical importance of this time frame and early congruence between the emergency cardiac and trauma populations.

University of Washington DISCOVER Center; Lianne Sheppard, Director: Biostatistics Core; Kathleen Kerr, Adam Szpiro, Jon Wakefield: Co-Investigators. DISCOVER Center projects investigate the mechanistic relationship between cardiovascular disease and traffic-related air pollution.

Vaccine and Infectious Disease Institute (VIDI); Steve Self, Co-Director: The Vaccine and Infectious Disease Institute develops and implements prevention strategies for globally important infectious diseases, including HIV, malaria, and the viruses and bacteria that can result in cancer.

Statistical Center for HIV/AIDS Research & Prevention (SCHARP); Steve Self, Executive Director and Principal Investigator of HVTN; Peter Gilbert, Co- Principal Investigator of HVTN; Tom Fleming, Principal Investigator of HPTN; Barbara Richardson, Co-Principal Investigator of MTN. SCHARP provides statistical collaboration to HIV/AIDS researchers around the world and conducts a complementary program of statistical methodology and mathematical modeling research. SCHARP also collects, manages, and analyzes data from clinical trials and epidemiological studies dedicated to the elimination of HIV/AIDS as a threat to human health.

GENEVA Study Coordinating Center, Bruce Weir, Principal Investigator: Data from the genome-wide association studies will be deposited in the database of Genotypes and Phenotypes (dbGaP), at the National Center for Biotechnology Information, a part of the National Library of Medicine at NIH, which will manage the vast amount of genetic, medical and environmental information that emerges from GEI.

Northwest PRECEDENT, Timothy DeRouen, PhD, Principal Investigator and Network Chair; Brian Leroux, PhD, Principal Investigator, Data Coordinating Center: Operated jointly by the University of Washington and Oregon Health & Science University, Northwest PRECEDENT was created as one of three Dental Practice-Based Research Networks nationwide. These networks are focused on studying the practical issues facing dentists and their patients, and providing information that will improve the quality of oral health care as a whole.

Center for Ecogenetics and Environmental Health (CEEH); Kathleen Kerr, Director of Bioinformatics and Biostatistics Facility Core: The goals of CEEH include fostering collaborations between investigators working in toxicology, molecular biology, genetics, and environmental epidemiology to understand and communicate how genetic factors influence human susceptibility to environmental health risks. The Bioinformatics and Biostatistics Facility Core designs microarray studies in collaboration with investigators and provides comprehensive data management and analysis.

Autism Center of Excellence (ACE); Ellen Wijsman, Principal Investigator for “Genetic contributions to endophenotypes of autism.” The University of Washington ACE is one of 5 centers in the United States funded by NIH to foster interdisciplinary research on the biological basis of autism.

Alzheimer’s Disease Research Center (ADRC); Ellen Wijsman, Principal Investigator for Biostatistics Core and for Project 1. The University of Washington ADRC is one of 31 centers in the United States funded by NIH to foster and support interdisciplinary research on Alzheimer’s disease.

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